ERWINAZE® (asparaginase Erwinia chrysanthemi) is an asparagine specific enzyme indicated as a component of a multi-agent chemotherapeutic regimen for the treatment of patients with acute lymphoblastic leukemia (ALL) who have developed hypersensitivity to E. coli-derived asparaginase.
IMPORTANT SAFETY INFORMATION
ERWINAZE is part of a chemotherapy program to treat patients who have acute lymphoblastic leukemia (ALL), a type of blood cancer that affects the white blood cells that help fight infection. ERWINAZE is used in patients who have had an allergic reaction to a different type of asparaginase treatment. ERWINAZE is given as an injection (a shot) into a muscle or infusion into a vein.
ERWINAZE should not be given to people who have had:
- Serious allergic reactions to ERWINAZE
- Serious swelling of the pancreas (stomach pain), serious blood clots, or serious bleeding during prior L-asparaginase treatment
ERWINAZE may cause serious side effects, including:
- Allergic reactions (a feeling of tightness in the throat, unusual swelling/redness in the throat and/or tongue, or trouble breathing), some of which may be life-threatening
- Swelling of the pancreas (stomach pain)
- Too much sugar in your blood (may be thirsty or need to urinate often)
- Blood clots (may have headache or pain in leg, arm, or chest), or bleeding
Contact your doctor immediately if any of these side effects occur.
Some of the most common side effects with ERWINAZE include:
- Allergic reactions
- Too much sugar in the blood
- Swelling of the pancreas
- Local reactions (swelling, rash, etc. where the needle entered the skin)
- Feeling nauseous
- Blood clots (may have headache or pain in leg, arm, or chest)
- Liver problems
- Stomach pain/discomfort
ERWINAZE can harm your unborn baby. Inform your doctor if you are pregnant, planning to become pregnant, or nursing. Females of reproductive potential should use effective contraception (other than oral contraceptives) during treatment and for 3 months following the final dose. Do not breastfeed while receiving ERWINAZE and for 3 months after the final dose.
Tell your doctor if there are any side effects that are bothersome or that do not go away.
These are not all the possible side effects of ERWINAZE. For more information, ask your doctor.
Call your doctor for medical advice about any side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see full Prescribing Information and discuss ERWINAZE with your doctor.
The content contained in this website is not intended to be a substitute for professional medical advice related to any topic discussed. Patients are urged to consult with their treating physicians or other professionals. Never disregard professional, medical, or legal advice or delay seeking such advice because of something you have read on this website.